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M9480479.TXT
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1994-08-20
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Document 0479
DOCN M9480479
TI Polymerase chain reaction for rapid diagnosis of tuberculous meningitis
in AIDS patients.
DT 9410
AU Folgueira L; Delgado R; Palenque E; Noriega AR; Department of
Microbiology, Hospital Doce de Octubre, Madrid,; Spain.
SO Neurology. 1994 Jul;44(7):1336-8. Unique Identifier : AIDSLINE
MED/94309824
AB We used a test based on the polymerase chain reaction (PCR) for the
detection of Mycobacterium tuberculosis DNA in 11 CSF samples from 10
HIV-seropositive patients in whom tuberculous meningitis was suspected.
PCR was positive in nine samples from eight patients in whom clinical
data, CSF findings, evidence of tuberculosis at an extraneural site, and
response to antituberculous drug therapy supported the diagnosis,
whereas cultures were positive in five of these nine samples and
staining in only one. The PCR was negative in 14 CSF samples from the
control group.
DE Acquired Immunodeficiency Syndrome/*COMPLICATIONS Adult Base Sequence
DNA, Bacterial/CEREBROSPINAL FLUID Female Human Male Molecular
Probes/GENETICS Molecular Sequence Data Mycobacterium
tuberculosis/GENETICS *Polymerase Chain Reaction Support, Non-U.S.
Gov't Time Factors Tuberculosis, Meningeal/*DIAGNOSIS/ETIOLOGY
JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).